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KMID : 0617320030120010227
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Journal of Pharmacetical Sceiences Ewha Womans University
2003 Volume.12 No. 1 p.227 ~ p.230
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Synthesis and Biological Evaluation of Halo-neplanocin A as Novel Mechanism-Based Inhibitors of S-Adenosylhomocysteine Hydrolase
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Jeong, Lak Shin
Moon, Hyung Ryong/Park, Jae Gyu/Shin, Dae Hong/Choi, Won Jun/Lee, Kang Man/Kim, Hea Ok
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Abstract
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Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.
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